Zelmina Lubovac

Deputy Head of Department/Senior Lecturer

School of Bioscience

Contact info

• Email
• zelmina.lubovac@his.se

• Work
• 0500-448305

• Room
• G2248

Ph.D., M.Sc., B.Sc.

Ph.D., School for Humanities and Informatics, Sweden, and Heriot-Watt University, School of Mathematical and Computer Science, Edinburgh, Scotland, 2008

Member of the BioInformatics Group (BIG)

Research interest

Various methods of network clustering have been applied to reveal modular organisation in protein interaction networks (PINs). However, those clustering methods are mostly based on topological properties of the network. Therefore, we are focusing on developing methods for deriving functional modules from PINs using both structural information and domain knowledge from Gene Ontology. The modules obtained by these integrated methods are characterised by high functional cohesiveness among their members. Besides deriving modular structure, we also use the proposed methods to shed light on how the functional strength of interactions affects our view of global structural organization. 

Publications

• 2008
  Temporal analysis of oncogenesis using microRNA expression data
  Zichner Thomas, Lubovac Zelmina, Olsson Björn
  Proc. Ger. Conf. Bioinformatics, GCB (128-137). Bonn: Gesellschaft für Informatik, 2008.
• 2007
  Weighted Cohesiveness for Identification of Functional Modules and their Interconnectivity
  Lubovac Zelmina, Corne David, Gamalielsson Jonas et al.
  Bioinformatics Research and Development: First International Conference, BIRD ’07 (185-198). Springer Berlin/Heidelberg, 2007.
• 2006
  Combining functional and topological properties to identify core modules in protein interaction networks
  Lubovac Zelmina, Gamalielsson Jonas, Olsson Björn
  Proteins: Structure, Function, and Bioinformatics, 2006, 64(4), 948-959.
• Thesis Materials: Knowledge-based Methods for Identification of Functional Modules in Protein Interaction Networks
  Lubovac Zelmina
  Skövde: Institutionen för kommunikation och information, 2006. [Full text]
• Weighted Clustering Coefficient for Identifying Modular Formations in Protein-Protein Interaction Networks
  Lubovac Zelmina, Olsson Björn, Gamalielsson Jonas
  Proceedings of World Academy of Science, Engineering and Technology, Vol 14 (122-127). World Academy of Science, Engineering and Technology, 2006.
• 2005
  Combining topological characteristics and domain knowledge reveals functional modules in protein interaction networks
  Lubovac Zelmina, Olsson Björn, Gamalielsson Jonas
  Proceedings of CompBioNets 2005: Algorithms and Computational Methods for Biochemical and Evolutionary Networks (93-106). 2005.
• Exploring protein networks with a semantic similarity measure across Gene Ontology
  Lubovac Zelmina, Gamalielsson Jonas, Olsson Björn et al.
  Proceedings of the 8th Joint Conference on Information Sciences, Vols 1-3 (1203-1208). Durham, NC: Joint Conference on Information Sciences, 2005.
• Simulations of simple artificial genetic networks reveal features in the use of Relevance Networks
  Lindlöf Angelica, Lubovac Zelmina
  In Silico Biology, 2005, 5(3), 239-249.
• 2003
  Towards Reverse Engineering of Genetic Regulatory Networks
  Lubovac Zelmina, Olsson Björn
  Skövde: Institutionen för kommunikation och information, 2003. [Full text]

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