Genes as targets for cancer treatment
We investigate genes that cause cancer aggressiveness. We specifically focus on the childhood cancer tumor neuroblastoma, which occurs in the nervous system of young children. Some tumors are more aggressive than others, and the difference is what has happened to the genes in the tumor. If the tumor has lost some of the genes on chromosome 11, the child has a poor prognosis. We test the properties of genes that have been lost, to see if those specific lost properties are something that will benefit the tumor cell. We want to replace those properties through different types of treatments, and in this way kill the tumor cell. We analyze clinical/genetic data and make experiments in cultured cells and in fruit flies.
January 2015 - July 2021 DHEAR – for a healthier and more sustainable soci